Assay Detail
Binding
CHEMBL960157
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Inhibition of human recombinant caspase 1 assessed as accumulation of fluorogenic product by fluorometric assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.57 | 8.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL37630 | — | — | 1 | 8.08 |
| CHEMBL516251 | — | — | 1 | 5.48 |
| CHEMBL492060 | — | — | 1 | 5.41 |
| CHEMBL519148 | — | — | 1 | 5.39 |
| CHEMBL476023 | — | — | 1 | 5.38 |
| CHEMBL490850 | — | — | 1 | 5.37 |
| CHEMBL523131 | — | — | 1 | 5.34 |
| CHEMBL477047 | — | — | 1 | 5.33 |
| CHEMBL477659 | — | — | 1 | 5.33 |
| CHEMBL490851 | — | — | 1 | 5.27 |
| CHEMBL521972 | — | — | 1 | 5.27 |
| CHEMBL492061 | — | — | 1 | 5.17 |
| CHEMBL482841 | — | — | 1 | - |
| CHEMBL521801 | — | — | 1 | - |
| CHEMBL492059 | — | — | 1 | - |
| CHEMBL476022 | — | — | 1 | - |
| CHEMBL510809 | — | — | 1 | - |
| CHEMBL478694 | — | — | 1 | - |
| CHEMBL484273 | — | — | 1 | - |
| CHEMBL482634 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL37630 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL516251 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL492060 | — | IC50 | = | 3875.0 | nM | 5.41 |
| CHEMBL519148 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL476023 | — | IC50 | = | 4183.0 | nM | 5.38 |
| CHEMBL490850 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL523131 | — | IC50 | = | 4575.0 | nM | 5.34 |
| CHEMBL477047 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL477659 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL490851 | — | IC50 | = | 5350.0 | nM | 5.27 |
| CHEMBL521972 | — | IC50 | = | 5350.0 | nM | 5.27 |
| CHEMBL492061 | — | IC50 | = | 6825.0 | nM | 5.17 |
| CHEMBL482841 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL521801 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL492059 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL476022 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL510809 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL478694 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL484273 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL482634 | — | IC50 | > | 25000.0 | nM | - |