Assay Detail
Binding
CHEMBL960158
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Inhibition of human recombinant caspase 3 assessed as accumulation of fluorogenic product by fluorometric assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.31 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL417149 | — | — | 1 | 8.66 |
| CHEMBL439753 | — | — | 1 | 7.84 |
| CHEMBL226779 | — | — | 1 | 7.56 |
| CHEMBL476022 | — | — | 1 | 6.94 |
| CHEMBL516251 | — | — | 1 | 6.49 |
| CHEMBL510809 | — | — | 1 | 6.44 |
| CHEMBL492059 | — | — | 1 | 6.28 |
| CHEMBL519148 | — | — | 1 | 6.23 |
| CHEMBL477659 | — | — | 1 | 6.17 |
| CHEMBL477047 | — | — | 1 | 6.17 |
| CHEMBL478694 | — | — | 1 | 6.14 |
| CHEMBL476023 | — | — | 1 | 6.14 |
| CHEMBL482841 | — | — | 1 | 5.99 |
| CHEMBL521801 | — | — | 1 | 5.85 |
| CHEMBL482634 | — | — | 1 | 5.84 |
| CHEMBL523131 | — | — | 1 | 5.84 |
| CHEMBL521972 | — | — | 1 | 5.81 |
| CHEMBL490850 | — | — | 1 | 5.78 |
| CHEMBL490851 | — | — | 1 | 5.70 |
| CHEMBL492061 | — | — | 1 | 5.33 |
| CHEMBL492060 | — | — | 1 | 5.33 |
| CHEMBL484273 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL417149 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL439753 | — | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL226779 | — | IC50 | = | 27.8 | nM | 7.56 |
| CHEMBL476022 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL516251 | — | IC50 | = | 323.0 | nM | 6.49 |
| CHEMBL510809 | — | IC50 | = | 365.0 | nM | 6.44 |
| CHEMBL492059 | — | IC50 | = | 529.0 | nM | 6.28 |
| CHEMBL519148 | — | IC50 | = | 583.0 | nM | 6.23 |
| CHEMBL477659 | — | IC50 | = | 673.0 | nM | 6.17 |
| CHEMBL477047 | — | IC50 | = | 671.0 | nM | 6.17 |
| CHEMBL478694 | — | IC50 | = | 724.0 | nM | 6.14 |
| CHEMBL476023 | — | IC50 | = | 718.0 | nM | 6.14 |
| CHEMBL482841 | — | IC50 | = | 1028.0 | nM | 5.99 |
| CHEMBL521801 | — | IC50 | = | 1405.0 | nM | 5.85 |
| CHEMBL482634 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL523131 | — | IC50 | = | 1454.0 | nM | 5.84 |
| CHEMBL521972 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL490850 | — | IC50 | = | 1672.0 | nM | 5.78 |
| CHEMBL490851 | — | IC50 | = | 1993.0 | nM | 5.70 |
| CHEMBL492061 | — | IC50 | = | 4633.0 | nM | 5.33 |
| CHEMBL492060 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL484273 | — | IC50 | > | 20000.0 | nM | - |