Assay Detail
Functional
CHEMBL960180
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Antiviral activity against Varicella Zoster virus Oka infected in HEL cells assessed as reduction in viral plaque formation after 5 days
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 3 |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Alkenyl substituted bicyclic nucleoside analogues retain nanomolar potency against Varicella Zoster Virus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 7.01 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL484070 | — | — | 1 | 9.52 |
| CHEMBL485095 | — | — | 1 | 9.22 |
| CHEMBL344738 | CF1743 | — | 1 | 9.22 |
| CHEMBL146212 | — | — | 1 | 8.80 |
| CHEMBL489047 | — | — | 1 | 8.40 |
| CHEMBL147162 | — | — | 1 | 7.96 |
| CHEMBL521178 | — | — | 1 | 5.96 |
| CHEMBL522752 | — | — | 1 | 5.72 |
| CHEMBL444555 | — | — | 1 | 5.08 |
| CHEMBL523439 | — | — | 1 | 4.92 |
| CHEMBL489647 | — | — | 1 | 4.89 |
| CHEMBL489048 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL484070 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL485095 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL344738 | CF1743 | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL146212 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL489047 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL147162 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL521178 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL522752 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL444555 | — | EC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL523439 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL489647 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL489048 | — | EC50 | = | 33000.0 | nM | 4.48 |