Assay Detail
Functional
CHEMBL960181
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Varicella Zoster virus YS infected in HEL cells assessed as reduction in viral plaque formation after 5 days
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 3 |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Alkenyl substituted bicyclic nucleoside analogues retain nanomolar potency against Varicella Zoster Virus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.62 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL146212 | — | — | 1 | 9.30 |
| CHEMBL344738 | CF1743 | — | 1 | 9.30 |
| CHEMBL484070 | — | — | 1 | 9.10 |
| CHEMBL147162 | — | — | 1 | 8.52 |
| CHEMBL489047 | — | — | 1 | 8.40 |
| CHEMBL485095 | — | — | 1 | 8.15 |
| CHEMBL521178 | — | — | 1 | 5.89 |
| CHEMBL522752 | — | — | 1 | 5.64 |
| CHEMBL489647 | — | — | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL146212 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL344738 | CF1743 | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL484070 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL147162 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL489047 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL485095 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL521178 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL522752 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL489647 | — | EC50 | = | 58000.0 | nM | 4.24 |