Assay Detail
Binding
CHEMBL960184
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and synthesis of 3-phenyltetrahydronaphthalenic derivatives as new selective MT2 melatoninergic ligands. Part II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 7.08 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.85 |
| CHEMBL477447 | — | — | 1 | 7.89 |
| CHEMBL522811 | — | — | 1 | 7.69 |
| CHEMBL491058 | — | — | 1 | 7.48 |
| CHEMBL491249 | — | — | 1 | 7.46 |
| CHEMBL491053 | — | — | 1 | 7.35 |
| CHEMBL477448 | — | — | 1 | 7.29 |
| CHEMBL515629 | — | — | 1 | 7.21 |
| CHEMBL285718 | — | — | 1 | 6.97 |
| CHEMBL489223 | — | — | 1 | 6.90 |
| CHEMBL477048 | — | — | 1 | 6.61 |
| CHEMBL489224 | — | — | 1 | 6.51 |
| CHEMBL491052 | — | — | 1 | 6.36 |
| CHEMBL443934 | — | — | 1 | 6.09 |
| CHEMBL489825 | — | — | 1 | 6.01 |
| CHEMBL523768 | — | — | 1 | 5.61 |
| CHEMBL489416 | — | — | 1 | - |
| CHEMBL517811 | — | — | 1 | - |
| CHEMBL477662 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45 | MELATONIN | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL477447 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL522811 | — | Ki | = | 20.5 | nM | 7.69 |
| CHEMBL491058 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL491249 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL491053 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL477448 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL515629 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL285718 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL489223 | — | Ki | = | 127.0 | nM | 6.90 |
| CHEMBL477048 | — | Ki | = | 247.0 | nM | 6.61 |
| CHEMBL489224 | — | Ki | = | 311.0 | nM | 6.51 |
| CHEMBL491052 | — | Ki | = | 439.0 | nM | 6.36 |
| CHEMBL443934 | — | Ki | = | 809.0 | nM | 6.09 |
| CHEMBL489825 | — | Ki | = | 981.0 | nM | 6.01 |
| CHEMBL523768 | — | Ki | = | 2480.0 | nM | 5.61 |
| CHEMBL489416 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL517811 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL477662 | — | Ki | > | 1000.0 | nM | - |