Assay Detail
Binding
CHEMBL960185
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 2-[125I]iodomelatonin from human MT2 receptor stably transfected in cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and synthesis of 3-phenyltetrahydronaphthalenic derivatives as new selective MT2 melatoninergic ligands. Part II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 8.73 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL491249 | — | — | 1 | 10.00 |
| CHEMBL491058 | — | — | 1 | 9.82 |
| CHEMBL491053 | — | — | 1 | 9.80 |
| CHEMBL522811 | — | — | 1 | 9.51 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.39 |
| CHEMBL489223 | — | — | 1 | 9.18 |
| CHEMBL477448 | — | — | 1 | 9.11 |
| CHEMBL477447 | — | — | 1 | 9.06 |
| CHEMBL477048 | — | — | 1 | 9.05 |
| CHEMBL285718 | — | — | 1 | 9.02 |
| CHEMBL489224 | — | — | 1 | 8.98 |
| CHEMBL443934 | — | — | 1 | 8.72 |
| CHEMBL491052 | — | — | 1 | 8.65 |
| CHEMBL515629 | — | — | 1 | 8.22 |
| CHEMBL523768 | — | — | 1 | 8.18 |
| CHEMBL489825 | — | — | 1 | 8.05 |
| CHEMBL477662 | — | — | 1 | 7.28 |
| CHEMBL489416 | — | — | 1 | 7.15 |
| CHEMBL517811 | — | — | 1 | 6.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL491249 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL491058 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL491053 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL522811 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL45 | MELATONIN | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL489223 | — | Ki | = | 0.66 | nM | 9.18 |
| CHEMBL477448 | — | Ki | = | 0.78 | nM | 9.11 |
| CHEMBL477447 | — | Ki | = | 0.88 | nM | 9.06 |
| CHEMBL477048 | — | Ki | = | 0.89 | nM | 9.05 |
| CHEMBL285718 | — | Ki | = | 0.96 | nM | 9.02 |
| CHEMBL489224 | — | Ki | = | 1.04 | nM | 8.98 |
| CHEMBL443934 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL491052 | — | Ki | = | 2.23 | nM | 8.65 |
| CHEMBL515629 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL523768 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL489825 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL477662 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL489416 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL517811 | — | Ki | = | 173.0 | nM | 6.76 |