Assay Detail
Functional
CHEMBL960190
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Agonist activity at human MT2 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and synthesis of 3-phenyltetrahydronaphthalenic derivatives as new selective MT2 melatoninergic ligands. Part II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 9.18 | 9.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL491249 | — | — | 1 | 9.39 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.31 |
| CHEMBL491058 | — | — | 1 | 9.13 |
| CHEMBL522811 | — | — | 1 | 8.89 |
| CHEMBL491052 | — | — | 1 | - |
| CHEMBL523768 | — | — | 1 | - |
| CHEMBL477048 | — | — | 1 | - |
| CHEMBL477447 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL491249 | — | EC50 | = | 0.41 | nM | 9.39 |
| CHEMBL45 | MELATONIN | EC50 | = | 0.49 | nM | 9.31 |
| CHEMBL491058 | — | EC50 | = | 0.74 | nM | 9.13 |
| CHEMBL522811 | — | EC50 | = | 1.28 | nM | 8.89 |
| CHEMBL491052 | — | EC50 | - | — | - | |
| CHEMBL523768 | — | EC50 | - | — | - | |
| CHEMBL477048 | — | EC50 | - | — | - | |
| CHEMBL477447 | — | EC50 | - | — | - |