Assay Detail
Binding
CHEMBL960588
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Inhibition of bovine erythrocyte AChE by Ellman's assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.29 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3216655 | — | — | 1 | 10.05 |
| CHEMBL3216886 | — | — | 1 | 9.54 |
| CHEMBL3216422 | — | — | 1 | 9.24 |
| CHEMBL3217103 | — | — | 1 | 9.09 |
| CHEMBL3216209 | — | — | 1 | 9.09 |
| CHEMBL2448138 | 9-[(2-{4-[(5,6-Dimethoxy-1-oxoindan-2-yl)methyl]piperidin-1-yl}ethyl)amino]-1,2,3,4-tetrahydroacridine dihydrochloride | — | 1 | 8.76 |
| CHEMBL3216210 | — | — | 1 | 8.73 |
| CHEMBL3216208 | — | — | 1 | 8.64 |
| CHEMBL486698 | — | — | 1 | 8.24 |
| CHEMBL1678 | DONEPEZIL HYDROCHLORIDE | 4.0 | 1 | 8.09 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 7.72 |
| CHEMBL484306 | — | — | 1 | 7.60 |
| CHEMBL1677 | TACRINE HYDROCHLORIDE | 4.0 | 1 | 6.89 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.78 |
| CHEMBL486699 | — | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3216655 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL3216886 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL3216422 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL3217103 | — | IC50 | = | 0.82 | nM | 9.09 |
| CHEMBL3216209 | — | IC50 | = | 0.82 | nM | 9.09 |
| CHEMBL2448138 | 9-[(2-{4-[(5,6-Dimethoxy-1-oxoindan-2-yl)methyl]piperidin-1-yl}ethyl)amino]-1,2,3,4-tetrahydroacridine dihydrochloride | IC50 | = | 1.74 | nM | 8.76 |
| CHEMBL3216210 | — | IC50 | = | 1.86 | nM | 8.73 |
| CHEMBL3216208 | — | IC50 | = | 2.28 | nM | 8.64 |
| CHEMBL486698 | — | IC50 | = | 5.73 | nM | 8.24 |
| CHEMBL1678 | DONEPEZIL HYDROCHLORIDE | IC50 | = | 8.12 | nM | 8.09 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL484306 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1677 | TACRINE HYDROCHLORIDE | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL95 | TACRINE | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL486699 | — | IC50 | = | 1451.0 | nM | 5.84 |