Assay Detail
Binding
CHEMBL960589
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human erythrocyte AChE by Ellman's assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.49 | 9.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3216655 | — | — | 1 | 9.57 |
| CHEMBL3216422 | — | — | 1 | 9.17 |
| CHEMBL3216886 | — | — | 1 | 9.06 |
| CHEMBL3217103 | — | — | 1 | 8.97 |
| CHEMBL3216209 | — | — | 1 | 8.67 |
| CHEMBL3216210 | — | — | 1 | 8.59 |
| CHEMBL2448138 | 9-[(2-{4-[(5,6-Dimethoxy-1-oxoindan-2-yl)methyl]piperidin-1-yl}ethyl)amino]-1,2,3,4-tetrahydroacridine dihydrochloride | — | 1 | 8.39 |
| CHEMBL3216208 | — | — | 1 | 8.29 |
| CHEMBL486698 | — | — | 1 | 8.08 |
| CHEMBL1678 | DONEPEZIL HYDROCHLORIDE | 4.0 | 1 | 7.94 |
| CHEMBL1677 | TACRINE HYDROCHLORIDE | 4.0 | 1 | 6.69 |
| CHEMBL486699 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3216655 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL3216422 | — | IC50 | = | 0.67 | nM | 9.17 |
| CHEMBL3216886 | — | IC50 | = | 0.88 | nM | 9.06 |
| CHEMBL3217103 | — | IC50 | = | 1.06 | nM | 8.97 |
| CHEMBL3216209 | — | IC50 | = | 2.16 | nM | 8.67 |
| CHEMBL3216210 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL2448138 | 9-[(2-{4-[(5,6-Dimethoxy-1-oxoindan-2-yl)methyl]piperidin-1-yl}ethyl)amino]-1,2,3,4-tetrahydroacridine dihydrochloride | IC50 | = | 4.04 | nM | 8.39 |
| CHEMBL3216208 | — | IC50 | = | 5.13 | nM | 8.29 |
| CHEMBL486698 | — | IC50 | = | 8.32 | nM | 8.08 |
| CHEMBL1678 | DONEPEZIL HYDROCHLORIDE | IC50 | = | 11.6 | nM | 7.94 |
| CHEMBL1677 | TACRINE HYDROCHLORIDE | IC50 | = | 205.0 | nM | 6.69 |
| CHEMBL486699 | — | IC50 | - | — | - |