Assay Detail
Binding
CHEMBL960834
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant PDE4B by scintillation proximity assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 4B (CHEMBL275) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Quinolines as a novel structural class of potent and selective PDE4 inhibitors: optimisation for oral administration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.96 | 9.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL473764 | — | — | 1 | 9.50 |
| CHEMBL193240 | ROFLUMILAST | 4.0 | 1 | 9.40 |
| CHEMBL473560 | — | — | 1 | 9.40 |
| CHEMBL515240 | — | — | 1 | 8.80 |
| CHEMBL517766 | — | — | 1 | 8.60 |
| CHEMBL462150 | — | — | 1 | 8.40 |
| CHEMBL515098 | — | — | 1 | 8.30 |
| CHEMBL517590 | — | — | 1 | 8.20 |
| CHEMBL463417 | — | — | 1 | 7.80 |
| CHEMBL463418 | — | — | 1 | 7.70 |
| CHEMBL461111 | — | — | 1 | 7.50 |
| CHEMBL464009 | — | — | 1 | 7.10 |
| CHEMBL517900 | — | — | 1 | 7.00 |
| CHEMBL464207 | — | — | 1 | 7.00 |
| CHEMBL473550 | — | — | 1 | 6.60 |
| CHEMBL514940 | — | — | 1 | 6.30 |
| CHEMBL472958 | — | — | 1 | 6.00 |
| CHEMBL514301 | — | — | 1 | 5.50 |
| CHEMBL461989 | — | — | 1 | 5.50 |
| CHEMBL464615 | — | — | 1 | 5.30 |
| CHEMBL473355 | — | — | 1 | 5.10 |
| CHEMBL473551 | — | — | 1 | 4.90 |
| CHEMBL473153 | — | — | 1 | 4.80 |
| CHEMBL461990 | — | — | 1 | 4.70 |
| CHEMBL473152 | — | — | 1 | 4.70 |
| CHEMBL462152 | — | — | 1 | - |
| CHEMBL462151 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL473764 | — | IC50 | = | 0.3162 | nM | 9.50 |
| CHEMBL193240 | ROFLUMILAST | IC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL473560 | — | IC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL515240 | — | IC50 | = | 1.585 | nM | 8.80 |
| CHEMBL517766 | — | IC50 | = | 2.512 | nM | 8.60 |
| CHEMBL462150 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL515098 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL517590 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL463417 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL463418 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL461111 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL464009 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL517900 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL464207 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL473550 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL514940 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL472958 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL514301 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL461989 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL464615 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL473355 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL473551 | — | IC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL473153 | — | IC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL461990 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL473152 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL462152 | — | IC50 | > | 31622.78 | nM | - |
| CHEMBL462151 | — | IC50 | > | 31622.78 | nM | - |