Assay Detail
Binding
CHEMBL960872
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Nuak1
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.89 | 6.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1615278 | — | — | 1 | 6.08 |
| CHEMBL1794070 | GSK-579289A | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1615278 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL1794070 | GSK-579289A | IC50 | = | 2000.0 | nM | 5.70 |