Assay Detail
Binding
CHEMBL960944
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Inhibition of TPR-fused Met phosphorylation expressed in human 293T cells by ELISA
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | 293T |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
N-(3-fluoro-4-(2-arylthieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: a novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.75 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL453613 | — | — | 1 | 7.40 |
| CHEMBL254760 | — | — | 1 | 7.30 |
| CHEMBL464211 | — | — | 1 | 7.30 |
| CHEMBL445871 | — | — | 1 | 7.22 |
| CHEMBL462835 | — | — | 1 | 7.22 |
| CHEMBL465131 | — | — | 1 | 7.22 |
| CHEMBL518676 | — | — | 1 | 7.10 |
| CHEMBL503016 | — | — | 1 | 7.10 |
| CHEMBL517469 | — | — | 1 | 7.00 |
| CHEMBL462232 | — | — | 1 | 6.92 |
| CHEMBL510676 | — | — | 1 | 6.92 |
| CHEMBL455655 | — | — | 1 | 6.85 |
| CHEMBL465130 | — | — | 1 | 6.80 |
| CHEMBL459478 | — | — | 1 | 6.68 |
| CHEMBL502621 | — | — | 1 | 6.64 |
| CHEMBL447616 | — | — | 1 | 6.60 |
| CHEMBL448993 | — | — | 1 | 6.57 |
| CHEMBL449757 | — | — | 1 | 6.52 |
| CHEMBL508776 | — | — | 1 | 6.52 |
| CHEMBL464510 | — | — | 1 | 6.51 |
| CHEMBL503524 | — | — | 1 | 6.50 |
| CHEMBL518209 | — | — | 1 | 6.43 |
| CHEMBL448276 | — | — | 1 | 6.38 |
| CHEMBL508395 | — | — | 1 | 6.08 |
| CHEMBL462231 | — | — | 1 | 6.00 |
| CHEMBL462667 | — | — | 1 | 5.84 |
| CHEMBL464409 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL453613 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL254760 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL464211 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL445871 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL462835 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL465131 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL518676 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL503016 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL517469 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL462232 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL510676 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL455655 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL465130 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL459478 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL502621 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL447616 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL448993 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL449757 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL508776 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL464510 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL503524 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL518209 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL448276 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL508395 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL462231 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL462667 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL464409 | — | IC50 | > | 10000.0 | nM | - |