Assay Detail
Binding
CHEMBL960948
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-fused recombinant c-Met catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins by DELFIA assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | BTI-TN-5B1-4 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
N-(3-fluoro-4-(2-arylthieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: a novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.36 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL503016 | — | — | 1 | 7.80 |
| CHEMBL449757 | — | — | 1 | 7.68 |
| CHEMBL517469 | — | — | 1 | 7.68 |
| CHEMBL448276 | — | — | 1 | 7.66 |
| CHEMBL462232 | — | — | 1 | 7.64 |
| CHEMBL518676 | — | — | 1 | 7.62 |
| CHEMBL455655 | — | — | 1 | 7.62 |
| CHEMBL490965 | — | — | 1 | 7.60 |
| CHEMBL453613 | — | — | 1 | 7.60 |
| CHEMBL462835 | — | — | 1 | 7.58 |
| CHEMBL510676 | — | — | 1 | 7.58 |
| CHEMBL464211 | — | — | 1 | 7.57 |
| CHEMBL508395 | — | — | 1 | 7.55 |
| CHEMBL465131 | — | — | 1 | 7.55 |
| CHEMBL464510 | — | — | 1 | 7.55 |
| CHEMBL447616 | — | — | 1 | 7.54 |
| CHEMBL508776 | — | — | 1 | 7.48 |
| CHEMBL445871 | — | — | 1 | 7.47 |
| CHEMBL503524 | — | — | 1 | 7.46 |
| CHEMBL518209 | — | — | 1 | 7.46 |
| CHEMBL254760 | — | — | 1 | 7.43 |
| CHEMBL459478 | — | — | 1 | 7.41 |
| CHEMBL502621 | — | — | 1 | 7.38 |
| CHEMBL465130 | — | — | 1 | 7.37 |
| CHEMBL462231 | — | — | 1 | 7.17 |
| CHEMBL448993 | — | — | 1 | 6.70 |
| CHEMBL462023 | — | — | 1 | 6.52 |
| CHEMBL462667 | — | — | 1 | 6.00 |
| CHEMBL464409 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL503016 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL449757 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL517469 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL448276 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL462232 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL518676 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL455655 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL490965 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL453613 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL462835 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL510676 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL464211 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL508395 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL465131 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL464510 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL447616 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL508776 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL445871 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL503524 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL518209 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL254760 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL459478 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL502621 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL465130 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL462231 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL448993 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL462023 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL462667 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL464409 | — | IC50 | = | 2000.0 | nM | 5.70 |