Assay Detail

CHEMBL961034

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Binding affinity to alpha1 adrenergic receptor by competitive binding experiment

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET.

Herth MM, Kramer V, Piel M, Palner M, Riss PJ, Knudsen GM, Rösch F.
Bioorg Med Chem (2009) 17 : 2989 -3002
PubMed 19329329 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	2	7.62	8.34

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL62919	ALTANSERIN	2.0	1	8.34
CHEMBL74355	VOLINANSERIN	3.0	1	6.89

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL62919	ALTANSERIN	Ki	=	4.55	nM	8.34
CHEMBL74355	VOLINANSERIN	Ki	=	128.0	nM	6.89