Compound Detail

CHEMBL62919

ALTANSERIN

🧪 Phase II

Enter ChEMBL ID:

Free Research Context This compound will appear in recent viewed items on the research home for this browser.

🧪 Phase II

O=C(c1ccc(F)cc1)C1CCN(CCn2c(=S)[nH]c3ccccc3c2=O)CC1

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL62919
Name	ALTANSERIN
Phase	Phase II
Structure Type	MOL
InChI Key	SMYALUSCZJXWHG-UHFFFAOYSA-N

Altanserin Altanserina Altanserine

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

411.5

MW (Da)

3.79

ALogP

HBA

HBD

58.1

PSA (Å²)

0.51

QED

Ro5 Violations

Rot. Bonds

Molecule Type	Small molecule
Chirality	Achiral

USAN Stem	-anserin
USAN Year	1984

Ki 12 meas. best 9.89

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
5-hydroxytryptamine receptor 2A CHEMBL224	Ki	9.89	9.705	0.1	2
5-hydroxytryptamine receptor 2A CHEMBL322	Ki	9.89	9.5125	0.1	4
Unchecked CHEMBL612545	Ki	8.34	8.34	4.5	1
Alpha-1A adrenergic receptor CHEMBL319	Ki	8.3	8.3	5.0	1
5-hydroxytryptamine receptor 2C CHEMBL225	Ki	7.4	7.4	40.0	1
D(2) dopamine receptor CHEMBL217	Ki	7.21	7.21	62.0	1
D(2) dopamine receptor CHEMBL339	Ki	7.21	7.21	62.0	1
5-hydroxytryptamine receptor 1A CHEMBL214	Ki	5.8	5.8	1570.0	1

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
5-hydroxytryptamine receptor 2A	Ki	=	0.13	nM	9.89	Binding affinity to 5HT2A receptor	18187324
5-hydroxytryptamine receptor 2A	Ki	=	0.13	nM	9.89	Displacement of [3H]altanserine from rat cortical membrane 5HT2A receptor	19329329
5-hydroxytryptamine receptor 2A	Ki	=	0.13	nM	9.89	Displacement of [3H]-Ketanserin from rat frontal cortex 5-HT2A receptor	35939391
5-hydroxytryptamine receptor 2A	Ki	=	0.3	nM	9.52	Binding affinity against 5-hydroxytryptamine 2A receptor in humans	12014970
5-hydroxytryptamine receptor 2A	Ki	=	0.72	nM	9.14	Displacement of [3H]MDL from rat 5HT2A receptor expressed in GF62 cells by liqui...	19329329
5-hydroxytryptamine receptor 2A	Ki	=	0.74	nM	9.13	Displacement of [3H]MDL from rat 5HT2A receptor expressed in GF62 cells	18187324
Unchecked	Ki	=	4.55	nM	8.34	Binding affinity to alpha1 adrenergic receptor by competitive binding experiment	19329329
Alpha-1A adrenergic receptor	Ki	=	5.0	nM	8.3	Displacement of [3H]-WB4101 from rat forebrain alpha 1 adrenergic receptors	35939391
5-hydroxytryptamine receptor 2C	Ki	=	40.0	nM	7.4	Binding affinity to 5HT2C receptor by competitive binding experiment	19329329
D(2) dopamine receptor	Ki	=	62.0	nM	7.21	Binding affinity to dopamine D2 receptor by competitive binding experiment	19329329
D(2) dopamine receptor	Ki	=	62.0	nM	7.21	Displacement of [3H]-halopridol from rat striatum D2 receptors	35939391
5-hydroxytryptamine receptor 1A	Ki	=	1570.0	nM	5.8	Binding affinity to 5-HT1A receptor by competitive binding experiment	19329329

PubMed	DOI	Target Context	# Activities
18187324	10.1016/j.bmcl.2007.12.054	5-hydroxytryptamine receptor 2A	2
19329329	10.1016/j.bmc.2009.03.021	5-hydroxytryptamine receptor 2A	2
-	10.6019/CHEMBL4651402	SARS-CoV-2	2
-	10.6019/CHEMBL4808148	Histone deacetylase 6	2
12014970	10.1021/jm0200411	5-hydroxytryptamine receptor 2A	1
19329329	10.1016/j.bmc.2009.03.021	5-hydroxytryptamine receptor 1A	1
19329329	10.1016/j.bmc.2009.03.021	5-hydroxytryptamine receptor 2C	1
19329329	10.1016/j.bmc.2009.03.021	D(2) dopamine receptor	1
19329329	10.1016/j.bmc.2009.03.021	Unchecked	1
19329329	10.1016/j.bmc.2009.03.021	No relevant target	1
35939391	10.1021/acs.jmedchem.2c00633	5-hydroxytryptamine receptor 2A	1
35939391	10.1021/acs.jmedchem.2c00633	Alpha-1A adrenergic receptor	1
35939391	10.1021/acs.jmedchem.2c00633	D(2) dopamine receptor	1

Data from ChEMBL 36 via Core Engine