Assay Detail
Binding
CHEMBL961037
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Inhibition of human cloned 5HT2B receptor by competitive binding experiment
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.07 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL402143 | — | — | 1 | 6.52 |
| CHEMBL515472 | — | — | 1 | 6.50 |
| CHEMBL476839 | — | — | 1 | 6.33 |
| CHEMBL490632 | — | — | 1 | 6.25 |
| CHEMBL516088 | — | — | 1 | 6.02 |
| CHEMBL490634 | — | — | 1 | 5.98 |
| CHEMBL476838 | — | — | 1 | 5.73 |
| CHEMBL489408 | — | — | 1 | 5.71 |
| CHEMBL490633 | — | — | 1 | 5.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL402143 | — | Ki | = | 299.0 | nM | 6.52 |
| CHEMBL515472 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL476839 | — | Ki | = | 466.0 | nM | 6.33 |
| CHEMBL490632 | — | Ki | = | 559.0 | nM | 6.25 |
| CHEMBL516088 | — | Ki | = | 960.0 | nM | 6.02 |
| CHEMBL490634 | — | Ki | = | 1052.0 | nM | 5.98 |
| CHEMBL476838 | — | Ki | = | 1844.0 | nM | 5.73 |
| CHEMBL489408 | — | Ki | = | 1972.0 | nM | 5.71 |
| CHEMBL490633 | — | Ki | = | 2751.0 | nM | 5.56 |