Assay Detail
Binding
CHEMBL961253
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Inhibition of Fms by fluorescence polarization competition immunoassay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Macrophage colony-stimulating factor 1 receptor (CHEMBL1844) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pyrido[2,3-d]pyrimidin-5-ones: a novel class of antiinflammatory macrophage colony-stimulating factor-1 receptor inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 8.81 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL489684 | — | — | 1 | 9.52 |
| CHEMBL521580 | — | — | 1 | 9.40 |
| CHEMBL489881 | — | — | 1 | 9.40 |
| CHEMBL492809 | — | — | 1 | 9.40 |
| CHEMBL451575 | — | — | 1 | 9.30 |
| CHEMBL509044 | — | — | 1 | 9.30 |
| CHEMBL489298 | — | — | 1 | 9.30 |
| CHEMBL451918 | — | — | 1 | 9.15 |
| CHEMBL505830 | — | — | 1 | 9.15 |
| CHEMBL445519 | — | — | 1 | 9.15 |
| CHEMBL403776 | — | — | 1 | 9.10 |
| CHEMBL448339 | — | — | 1 | 9.10 |
| CHEMBL508935 | — | — | 1 | 9.10 |
| CHEMBL448117 | — | — | 1 | 9.10 |
| CHEMBL511484 | — | — | 1 | 8.92 |
| CHEMBL522834 | — | — | 1 | 8.89 |
| CHEMBL451931 | — | — | 1 | 8.89 |
| CHEMBL472403 | — | — | 1 | 8.85 |
| CHEMBL455591 | — | — | 1 | 8.77 |
| CHEMBL452965 | — | — | 1 | 8.66 |
| CHEMBL444454 | — | — | 1 | 8.62 |
| CHEMBL507619 | — | — | 1 | 8.49 |
| CHEMBL490080 | — | — | 1 | 8.39 |
| CHEMBL489883 | — | — | 1 | 8.30 |
| CHEMBL491078 | — | — | 1 | 8.28 |
| CHEMBL450914 | — | — | 1 | 8.15 |
| CHEMBL414001 | — | — | 1 | 7.89 |
| CHEMBL523802 | — | — | 1 | 7.82 |
| CHEMBL514153 | — | — | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL489684 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL521580 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL489881 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL492809 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL451575 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL509044 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL489298 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL451918 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL505830 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL445519 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL403776 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL448339 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL508935 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL448117 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL511484 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL522834 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL451931 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL472403 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL455591 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL452965 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL444454 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL507619 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL490080 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL489883 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL491078 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL450914 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL414001 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL523802 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL514153 | — | IC50 | = | 75.0 | nM | 7.12 |