Assay Detail
Functional
CHEMBL961467
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Antiviral activity against HIV1 in human C8116 cells assessed as reduction of p24 protein level after 4 days by ELISA
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | C8116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Pestaloficiols A-E, bioactive cyclopropane derivatives from the plant endophytic fungus Pestalotiopsis fici.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.45 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1735 | INDINAVIR SULFATE | 4.0 | 1 | 8.05 |
| CHEMBL519156 | PESTALOFICIOL A | — | 1 | 4.58 |
| CHEMBL500563 | PESTALOFICIOL D | — | 1 | 4.58 |
| CHEMBL446207 | PESTALOFICIOL B | — | 1 | 4.58 |
| CHEMBL483107 | PESTALOFICIOL C | — | 1 | - |
| CHEMBL482515 | PESTALOFICIOL E | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1735 | INDINAVIR SULFATE | EC50 | = | 8.81 | nM | 8.05 |
| CHEMBL519156 | PESTALOFICIOL A | EC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL500563 | PESTALOFICIOL D | EC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL446207 | PESTALOFICIOL B | EC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL483107 | PESTALOFICIOL C | EC50 | - | — | - | |
| CHEMBL482515 | PESTALOFICIOL E | EC50 | - | — | - |