Assay Detail
Functional
CHEMBL961553
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 replication in human wild type CEM/0 cells assessed as virus-induced cytopathic effect
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CEM/0 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
5-(1-Acetoxyvinyl)-cycloSaligenyl-2',3'-dideoxy-2',3'- didehydrothymidine monophosphates, a second type of new, enzymatically activated cycloSaligenyl pronucleotides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 6.30 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL462601 | — | — | 1 | 6.80 |
| CHEMBL516656 | — | — | 1 | 6.75 |
| CHEMBL517139 | — | — | 1 | 6.75 |
| CHEMBL460300 | — | — | 1 | 6.68 |
| CHEMBL222056 | — | — | 1 | 6.41 |
| CHEMBL510202 | — | — | 1 | 6.35 |
| CHEMBL516477 | — | — | 1 | 6.33 |
| CHEMBL460301 | — | — | 1 | 6.33 |
| CHEMBL506559 | — | — | 1 | 6.28 |
| CHEMBL459226 | — | — | 1 | 6.27 |
| CHEMBL455702 | — | — | 1 | 6.27 |
| CHEMBL376912 | — | — | 1 | 6.19 |
| CHEMBL462426 | — | — | 1 | 6.19 |
| CHEMBL502960 | — | — | 1 | 6.14 |
| CHEMBL462404 | — | — | 1 | 6.12 |
| CHEMBL461547 | — | — | 1 | 6.09 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 6.07 |
| CHEMBL455784 | — | — | 1 | 6.05 |
| CHEMBL459227 | — | — | 1 | 5.96 |
| CHEMBL454899 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL462601 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL516656 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL517139 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL460300 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL222056 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL510202 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL516477 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL460301 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL506559 | — | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL459226 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL455702 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL376912 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL462426 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL502960 | — | EC50 | = | 720.0 | nM | 6.14 |
| CHEMBL462404 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL461547 | — | EC50 | = | 810.0 | nM | 6.09 |
| CHEMBL991 | STAVUDINE | EC50 | = | 850.0 | nM | 6.07 |
| CHEMBL455784 | — | EC50 | = | 890.0 | nM | 6.05 |
| CHEMBL459227 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL454899 | — | EC50 | = | 1300.0 | nM | 5.89 |