Assay Detail
Functional
CHEMBL961554
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV2 replication in human wild type CEM/0 cells assessed as virus-induced cytopathic effect
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 2 |
| Cell Type | CEM/0 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 2 (CHEMBL380) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 2 |
Publication
5-(1-Acetoxyvinyl)-cycloSaligenyl-2',3'-dideoxy-2',3'- didehydrothymidine monophosphates, a second type of new, enzymatically activated cycloSaligenyl pronucleotides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 5.99 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL517139 | — | — | 1 | 6.40 |
| CHEMBL516656 | — | — | 1 | 6.29 |
| CHEMBL462601 | — | — | 1 | 6.16 |
| CHEMBL459226 | — | — | 1 | 6.12 |
| CHEMBL462426 | — | — | 1 | 6.10 |
| CHEMBL460300 | — | — | 1 | 6.10 |
| CHEMBL376912 | — | — | 1 | 6.10 |
| CHEMBL459227 | — | — | 1 | 6.08 |
| CHEMBL502960 | — | — | 1 | 6.07 |
| CHEMBL516477 | — | — | 1 | 6.06 |
| CHEMBL510202 | — | — | 1 | 6.06 |
| CHEMBL222056 | — | — | 1 | 6.00 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 5.96 |
| CHEMBL460301 | — | — | 1 | 5.96 |
| CHEMBL462404 | — | — | 1 | 5.92 |
| CHEMBL461547 | — | — | 1 | 5.85 |
| CHEMBL455784 | — | — | 1 | 5.72 |
| CHEMBL506559 | — | — | 1 | 5.70 |
| CHEMBL455702 | — | — | 1 | 5.66 |
| CHEMBL454899 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL517139 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL516656 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL462601 | — | EC50 | = | 690.0 | nM | 6.16 |
| CHEMBL459226 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL462426 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL460300 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL376912 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL459227 | — | EC50 | = | 840.0 | nM | 6.08 |
| CHEMBL502960 | — | EC50 | = | 850.0 | nM | 6.07 |
| CHEMBL516477 | — | EC50 | = | 880.0 | nM | 6.06 |
| CHEMBL510202 | — | EC50 | = | 870.0 | nM | 6.06 |
| CHEMBL222056 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL991 | STAVUDINE | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL460301 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL462404 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL461547 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL455784 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL506559 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL455702 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL454899 | — | EC50 | = | 3000.0 | nM | 5.52 |