Assay Detail
Functional
CHEMBL961555
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV2 replication in human thymidine kinase deficient CEM cells assessed as virus-induced cytopathic effect
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 2 |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 2 (CHEMBL380) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 2 |
Publication
5-(1-Acetoxyvinyl)-cycloSaligenyl-2',3'-dideoxy-2',3'- didehydrothymidine monophosphates, a second type of new, enzymatically activated cycloSaligenyl pronucleotides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 5.60 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL460300 | — | — | 1 | 6.57 |
| CHEMBL459226 | — | — | 1 | 6.54 |
| CHEMBL516656 | — | — | 1 | 6.26 |
| CHEMBL517139 | — | — | 1 | 6.14 |
| CHEMBL376912 | — | — | 1 | 6.11 |
| CHEMBL502960 | — | — | 1 | 5.85 |
| CHEMBL510202 | — | — | 1 | 5.77 |
| CHEMBL516477 | — | — | 1 | 5.77 |
| CHEMBL460301 | — | — | 1 | 5.77 |
| CHEMBL506559 | — | — | 1 | 5.62 |
| CHEMBL462601 | — | — | 1 | 5.58 |
| CHEMBL462404 | — | — | 1 | 5.55 |
| CHEMBL455784 | — | — | 1 | 5.44 |
| CHEMBL459227 | — | — | 1 | 5.41 |
| CHEMBL461547 | — | — | 1 | 5.00 |
| CHEMBL222056 | — | — | 1 | 4.82 |
| CHEMBL455702 | — | — | 1 | 4.44 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 4.16 |
| CHEMBL462426 | — | — | 1 | - |
| CHEMBL454899 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL460300 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL459226 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL516656 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL517139 | — | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL376912 | — | EC50 | = | 780.0 | nM | 6.11 |
| CHEMBL502960 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL510202 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL516477 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL460301 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL506559 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL462601 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL462404 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL455784 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL459227 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL461547 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL222056 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL455702 | — | EC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL991 | STAVUDINE | EC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL462426 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL454899 | — | EC50 | > | 50000.0 | nM | - |