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Assay Detail

CHEMBL961556

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human wild type CEM/0 cells
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type CCRF-CEM
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

ADMET (CHEMBL612558)
Type ADMET

Publication

5-(1-Acetoxyvinyl)-cycloSaligenyl-2',3'-dideoxy-2',3'- didehydrothymidine monophosphates, a second type of new, enzymatically activated cycloSaligenyl pronucleotides.
Gisch N, Pertenbreiter F, Balzarini J, Meier C.
J Med Chem (2008) 51 : 8115 -8123
PubMed 19053827 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 20 4.46 4.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL502960 1 4.85
CHEMBL459226 1 4.77
CHEMBL517139 1 4.75
CHEMBL376912 1 4.72
CHEMBL506559 1 4.70
CHEMBL460300 1 4.70
CHEMBL462601 1 4.57
CHEMBL222056 1 4.48
CHEMBL455784 1 4.40
CHEMBL461547 1 4.39
CHEMBL516477 1 4.31
CHEMBL510202 1 4.31
CHEMBL459227 1 4.29
CHEMBL516656 1 4.25
CHEMBL462404 1 4.19
CHEMBL460301 1 4.17
CHEMBL455702 1 4.02
CHEMBL462426 1 -
CHEMBL454899 1 -
CHEMBL991 STAVUDINE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL502960 EC50 = 14000.0 nM 4.85
CHEMBL459226 EC50 = 17000.0 nM 4.77
CHEMBL517139 EC50 = 18000.0 nM 4.75
CHEMBL376912 EC50 = 19000.0 nM 4.72
CHEMBL506559 EC50 = 20000.0 nM 4.70
CHEMBL460300 EC50 = 20000.0 nM 4.70
CHEMBL462601 EC50 = 27000.0 nM 4.57
CHEMBL222056 EC50 = 33000.0 nM 4.48
CHEMBL455784 EC50 = 40000.0 nM 4.40
CHEMBL461547 EC50 = 41000.0 nM 4.39
CHEMBL516477 EC50 = 49000.0 nM 4.31
CHEMBL510202 EC50 = 49000.0 nM 4.31
CHEMBL459227 EC50 = 51000.0 nM 4.29
CHEMBL516656 EC50 = 56000.0 nM 4.25
CHEMBL462404 EC50 = 64000.0 nM 4.19
CHEMBL460301 EC50 = 67000.0 nM 4.17
CHEMBL455702 EC50 = 96000.0 nM 4.02
CHEMBL462426 EC50 = 111000.0 nM -
CHEMBL454899 EC50 = 148000.0 nM -
CHEMBL991 STAVUDINE EC50 = 220000.0 nM -