Assay Detail
Functional
CHEMBL961669
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Cytotoxicity against human CNE cells after 72 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CNE |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.68 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL271295 | — | — | 1 | 5.62 |
| CHEMBL128729 | — | — | 1 | 5.17 |
| CHEMBL478689 | — | — | 1 | 4.75 |
| CHEMBL17205 | CYCLOVALONE | 2.0 | 1 | 4.75 |
| CHEMBL476847 | — | — | 1 | 4.48 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.48 |
| CHEMBL477256 | — | — | 1 | 4.11 |
| CHEMBL498590 | — | — | 1 | 4.05 |
| CHEMBL517667 | — | — | 1 | - |
| CHEMBL255963 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL271295 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL128729 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL478689 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL17205 | CYCLOVALONE | IC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL476847 | — | IC50 | = | 32800.0 | nM | 4.48 |
| CHEMBL140 | CURCUMIN | IC50 | = | 32800.0 | nM | 4.48 |
| CHEMBL477256 | — | IC50 | = | 77900.0 | nM | 4.11 |
| CHEMBL498590 | — | IC50 | = | 89800.0 | nM | 4.05 |
| CHEMBL517667 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL255963 | — | IC50 | = | 154000.0 | nM | - |