Assay Detail
Functional
CHEMBL961671
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Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 4.47 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL518575 | — | — | 1 | 5.64 |
| CHEMBL271295 | — | — | 1 | 5.48 |
| CHEMBL478481 | — | — | 1 | 5.17 |
| CHEMBL476455 | — | — | 1 | 4.80 |
| CHEMBL477052 | — | — | 1 | 4.61 |
| CHEMBL476601 | — | — | 1 | 4.61 |
| CHEMBL476218 | — | — | 1 | 4.53 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.45 |
| CHEMBL518736 | — | — | 1 | 4.45 |
| CHEMBL129134 | — | — | 1 | 4.38 |
| CHEMBL478482 | — | — | 1 | 4.27 |
| CHEMBL478480 | — | — | 1 | 4.26 |
| CHEMBL476423 | — | — | 1 | 4.23 |
| CHEMBL517667 | — | — | 1 | 4.13 |
| CHEMBL477255 | — | — | 1 | 4.10 |
| CHEMBL476632 | TENYLIDONE | 2.0 | 1 | 4.07 |
| CHEMBL270022 | — | — | 1 | 4.07 |
| CHEMBL476220 | — | — | 1 | 4.02 |
| CHEMBL477049 | — | — | 1 | 4.02 |
| CHEMBL477054 | — | — | 1 | 4.01 |
| CHEMBL255963 | — | — | 1 | - |
| CHEMBL517965 | — | — | 1 | - |
| CHEMBL477058 | — | — | 1 | - |
| CHEMBL477256 | — | — | 1 | - |
| CHEMBL387599 | — | — | 1 | - |
| CHEMBL477057 | — | — | 1 | - |
| CHEMBL17205 | CYCLOVALONE | 2.0 | 1 | - |
| CHEMBL476424 | — | — | 1 | - |
| CHEMBL477053 | — | — | 1 | - |
| CHEMBL515630 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL518575 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL271295 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL478481 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL476455 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL477052 | — | IC50 | = | 24300.0 | nM | 4.61 |
| CHEMBL476601 | — | IC50 | = | 24500.0 | nM | 4.61 |
| CHEMBL476218 | — | IC50 | = | 29400.0 | nM | 4.53 |
| CHEMBL140 | CURCUMIN | IC50 | = | 35900.0 | nM | 4.45 |
| CHEMBL518736 | — | IC50 | = | 35300.0 | nM | 4.45 |
| CHEMBL129134 | — | IC50 | = | 41500.0 | nM | 4.38 |
| CHEMBL478482 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL478480 | — | IC50 | = | 55300.0 | nM | 4.26 |
| CHEMBL476423 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL517667 | — | IC50 | = | 74100.0 | nM | 4.13 |
| CHEMBL477255 | — | IC50 | = | 78900.0 | nM | 4.10 |
| CHEMBL476632 | TENYLIDONE | IC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL270022 | — | IC50 | = | 85300.0 | nM | 4.07 |
| CHEMBL476220 | — | IC50 | = | 94600.0 | nM | 4.02 |
| CHEMBL477049 | — | IC50 | = | 96000.0 | nM | 4.02 |
| CHEMBL477054 | — | IC50 | = | 98700.0 | nM | 4.01 |
| CHEMBL255963 | — | IC50 | = | 123000.0 | nM | - |
| CHEMBL517965 | — | IC50 | = | 249000.0 | nM | - |
| CHEMBL477058 | — | IC50 | = | 102000.0 | nM | - |
| CHEMBL477256 | — | IC50 | = | 150000.0 | nM | - |
| CHEMBL387599 | — | IC50 | = | 117000.0 | nM | - |
| CHEMBL477057 | — | IC50 | = | 179000.0 | nM | - |
| CHEMBL17205 | CYCLOVALONE | IC50 | < | 10100.0 | nM | - |
| CHEMBL476424 | — | IC50 | < | 3700.0 | nM | - |
| CHEMBL477053 | — | IC50 | < | 12600.0 | nM | - |
| CHEMBL515630 | — | IC50 | < | 9340.0 | nM | - |
| CHEMBL476847 | — | IC50 | = | 109000.0 | nM | - |