Assay Detail
Functional
CHEMBL961672
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Cytotoxicity against human LS 174T cells after 72 hrs by MTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LS174T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 4.88 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL128729 | — | — | 1 | 5.43 |
| CHEMBL477061 | — | — | 1 | 5.41 |
| CHEMBL504452 | — | — | 1 | 5.40 |
| CHEMBL478481 | — | — | 1 | 5.38 |
| CHEMBL17205 | CYCLOVALONE | 2.0 | 1 | 5.34 |
| CHEMBL476623 | — | — | 1 | 5.25 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 5.19 |
| CHEMBL477256 | — | — | 1 | 5.13 |
| CHEMBL448838 | — | — | 1 | 5.05 |
| CHEMBL516886 | — | — | 1 | 5.04 |
| CHEMBL476455 | — | — | 1 | 4.94 |
| CHEMBL476218 | — | — | 1 | 4.61 |
| CHEMBL477052 | — | — | 1 | 4.32 |
| CHEMBL476601 | — | — | 1 | 4.23 |
| CHEMBL255963 | — | — | 1 | 4.10 |
| CHEMBL477057 | — | — | 1 | 4.07 |
| CHEMBL476220 | — | — | 1 | 4.00 |
| CHEMBL515630 | — | — | 1 | - |
| CHEMBL478689 | — | — | 1 | - |
| CHEMBL477054 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL128729 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL477061 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL504452 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL478481 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL17205 | CYCLOVALONE | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL476623 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL140 | CURCUMIN | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL477256 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL448838 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL516886 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL476455 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL476218 | — | IC50 | = | 24300.0 | nM | 4.61 |
| CHEMBL477052 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL476601 | — | IC50 | = | 58800.0 | nM | 4.23 |
| CHEMBL255963 | — | IC50 | = | 79500.0 | nM | 4.10 |
| CHEMBL477057 | — | IC50 | = | 84500.0 | nM | 4.07 |
| CHEMBL476220 | — | IC50 | = | 98800.0 | nM | 4.00 |
| CHEMBL515630 | — | IC50 | = | 213000.0 | nM | - |
| CHEMBL478689 | — | IC50 | = | 103000.0 | nM | - |
| CHEMBL477054 | — | IC50 | = | 148000.0 | nM | - |