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Assay Detail

CHEMBL961844

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]alpha-bungarotoxin from Lymnaea stagnalis His-tagged AchBP
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Lymnaea stagnalis
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Acetylcholine-binding protein (CHEMBL6084)
Type SINGLE PROTEIN
Organism Lymnaea stagnalis

Publication

Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis.
Ulens C, Akdemir A, Jongejan A, van Elk R, Bertrand S, Perrakis A, Leurs R, Smit AB, Sixma TK, Bertrand D, de Esch IJ.
J Med Chem (2009) 52 : 2372 -2383
PubMed 19331415 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 16 6.43 7.20

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3 NICOTINE 4.0 1 7.20
CHEMBL490843 1 7.20
CHEMBL522249 1 7.00
CHEMBL491861 1 7.00
CHEMBL452172 1 6.90
CHEMBL522981 1 6.90
CHEMBL523130 1 6.50
CHEMBL491860 1 6.50
CHEMBL1946186 DEPTROPINE 2.0 1 6.40
CHEMBL490643 1 6.30
CHEMBL489034 1 6.20
CHEMBL490849 1 6.00
CHEMBL490442 1 5.90
CHEMBL522580 HEPZIDINE 2.0 1 5.80
CHEMBL489015 1 5.50
CHEMBL667 ACETYLCHOLINE 4.0 1 5.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3 NICOTINE Ki = 63.1 nM 7.20
CHEMBL490843 Ki = 63.1 nM 7.20
CHEMBL522249 Ki = 100.0 nM 7.00
CHEMBL491861 Ki = 100.0 nM 7.00
CHEMBL452172 Ki = 125.89 nM 6.90
CHEMBL522981 Ki = 125.89 nM 6.90
CHEMBL523130 Ki = 316.23 nM 6.50
CHEMBL491860 Ki = 316.23 nM 6.50
CHEMBL1946186 DEPTROPINE Ki = 398.11 nM 6.40
CHEMBL490643 Ki = 501.19 nM 6.30
CHEMBL489034 Ki = 630.96 nM 6.20
CHEMBL490849 Ki = 1000.0 nM 6.00
CHEMBL490442 Ki = 1258.93 nM 5.90
CHEMBL522580 HEPZIDINE Ki = 1584.89 nM 5.80
CHEMBL489015 Ki = 3162.28 nM 5.50
CHEMBL667 ACETYLCHOLINE Ki = 3162.28 nM 5.50