Assay Detail
ADMET
CHEMBL961998
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Cytotoxicity against rat L6 cells after 72 hrs by resazurin assay
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Cell Type | L6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Quinuclidine derivatives as potential antiparasitics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 51 | 4.65 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 7.85 |
| CHEMBL478532 | — | — | 1 | 4.97 |
| CHEMBL517819 | — | — | 1 | 4.96 |
| CHEMBL506578 | — | — | 1 | 4.87 |
| CHEMBL479211 | — | — | 1 | 4.80 |
| CHEMBL477326 | — | — | 1 | 4.79 |
| CHEMBL478724 | — | — | 1 | 4.78 |
| CHEMBL99679 | — | — | 1 | 4.69 |
| CHEMBL518134 | — | — | 1 | 4.62 |
| CHEMBL517057 | — | — | 1 | 4.59 |
| CHEMBL478723 | — | — | 1 | 4.42 |
| CHEMBL477322 | — | — | 1 | 4.41 |
| CHEMBL517050 | — | — | 1 | 4.40 |
| CHEMBL478339 | — | — | 1 | 4.35 |
| CHEMBL453439 | — | — | 1 | 4.33 |
| CHEMBL478533 | — | — | 1 | 4.30 |
| CHEMBL477492 | — | — | 1 | 4.26 |
| CHEMBL391926 | — | — | 1 | 4.13 |
| CHEMBL515183 | — | — | 1 | 4.10 |
| CHEMBL506873 | — | — | 1 | 4.01 |
| CHEMBL478981 | — | — | 1 | 4.00 |
| CHEMBL516895 | — | — | 1 | - |
| CHEMBL478340 | — | — | 1 | - |
| CHEMBL479189 | — | — | 1 | - |
| CHEMBL478359 | — | — | 1 | - |
| CHEMBL259665 | — | — | 1 | - |
| CHEMBL478913 | — | — | 1 | - |
| CHEMBL504277 | — | — | 1 | - |
| CHEMBL478912 | — | — | 1 | - |
| CHEMBL2094001 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL478532 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL517819 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL506578 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL479211 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL477326 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL478724 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL99679 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL518134 | — | IC50 | = | 23800.0 | nM | 4.62 |
| CHEMBL517057 | — | IC50 | = | 25600.0 | nM | 4.59 |
| CHEMBL478723 | — | IC50 | = | 37600.0 | nM | 4.42 |
| CHEMBL477322 | — | IC50 | = | 38900.0 | nM | 4.41 |
| CHEMBL517050 | — | IC50 | = | 40100.0 | nM | 4.40 |
| CHEMBL478339 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL453439 | — | IC50 | = | 47200.0 | nM | 4.33 |
| CHEMBL478533 | — | IC50 | = | 50400.0 | nM | 4.30 |
| CHEMBL477492 | — | IC50 | = | 55200.0 | nM | 4.26 |
| CHEMBL391926 | — | IC50 | = | 74500.0 | nM | 4.13 |
| CHEMBL515183 | — | IC50 | = | 78700.0 | nM | 4.10 |
| CHEMBL506873 | — | IC50 | = | 98200.0 | nM | 4.01 |
| CHEMBL478981 | — | IC50 | = | 98800.0 | nM | 4.00 |
| CHEMBL479212 | — | IC50 | > | 332000.0 | nM | - |
| CHEMBL518600 | — | IC50 | = | 193700.0 | nM | - |
| CHEMBL478347 | — | IC50 | > | 351000.0 | nM | - |
| CHEMBL478531 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL478530 | — | IC50 | > | 342000.0 | nM | - |
| CHEMBL478350 | — | IC50 | > | 370000.0 | nM | - |
| CHEMBL109405 | — | IC50 | = | 177000.0 | nM | - |
| CHEMBL478348 | — | IC50 | > | 287000.0 | nM | - |
| CHEMBL477327 | — | IC50 | = | 155400.0 | nM | - |
| CHEMBL505301 | — | IC50 | = | 175000.0 | nM | - |
| CHEMBL516436 | — | IC50 | > | 350000.0 | nM | - |
| CHEMBL442578 | — | IC50 | > | 370000.0 | nM | - |
| CHEMBL479223 | — | IC50 | > | 331700.0 | nM | - |
| CHEMBL443678 | — | IC50 | = | 171300.0 | nM | - |
| CHEMBL477305 | — | IC50 | = | 166000.0 | nM | - |
| CHEMBL478112 | — | IC50 | = | 169000.0 | nM | - |
| CHEMBL477079 | — | IC50 | = | 156000.0 | nM | - |
| CHEMBL478349 | — | IC50 | > | 338000.0 | nM | - |
| CHEMBL478358 | — | IC50 | = | 382000.0 | nM | - |
| CHEMBL445817 | — | IC50 | > | 394000.0 | nM | - |
| CHEMBL2094001 | — | IC50 | = | 212000.0 | nM | - |
| CHEMBL478912 | — | IC50 | = | 239000.0 | nM | - |
| CHEMBL504277 | — | IC50 | = | 136000.0 | nM | - |
| CHEMBL478913 | — | IC50 | > | 447000.0 | nM | - |
| CHEMBL259665 | — | IC50 | = | 265200.0 | nM | - |
| CHEMBL478359 | — | IC50 | > | 396000.0 | nM | - |
| CHEMBL479189 | — | IC50 | = | 152000.0 | nM | - |
| CHEMBL478340 | — | IC50 | = | 276100.0 | nM | - |
| CHEMBL516895 | — | IC50 | = | 101000.0 | nM | - |