Assay Detail
Binding
CHEMBL962086
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant ARK5
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of novel 3-aryl-4-(1H-indole-3yl)-1,5-dihydro-2H-pyrrole-2-ones as vascular endothelial growth factor receptor (VEGF-R) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.17 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL521201 | — | — | 1 | 5.75 |
| CHEMBL452812 | — | — | 1 | 5.70 |
| CHEMBL507056 | — | — | 1 | 5.44 |
| CHEMBL509435 | — | — | 1 | 5.31 |
| CHEMBL453593 | — | — | 1 | 4.47 |
| CHEMBL201511 | MALEIMIDE | — | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL521201 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL452812 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL507056 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL509435 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL453593 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL201511 | MALEIMIDE | IC50 | = | 43000.0 | nM | 4.37 |