Assay Detail
Functional
CHEMBL962341
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against taxol-sensitive human DLD1 cells after 72 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DLD-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Total synthesis and biological evaluation of potent analogues of dictyostatin: modification of the C2-C6 dienoate region.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.81 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL226880 | DICTYOSTATIN | — | 1 | 8.66 |
| CHEMBL461149 | — | — | 1 | 8.09 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.66 |
| CHEMBL459221 | — | — | 1 | 7.66 |
| CHEMBL364447 | DISERMOLIDE | 2.0 | 1 | 7.54 |
| CHEMBL479733 | — | — | 1 | 7.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL226880 | DICTYOSTATIN | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL461149 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL459221 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL364447 | DISERMOLIDE | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL479733 | — | IC50 | = | 55.0 | nM | 7.26 |