Assay Detail
Binding
CHEMBL962362
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Inhibition of rat hippocampus 5HT1A receptor by competitive binding assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Hippocampus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Benzimidazolone-based serotonin 5-HT1A or 5-HT7R ligands: synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 7.13 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL478680 | — | — | 1 | 8.47 |
| CHEMBL476463 | — | — | 1 | 8.22 |
| CHEMBL177064 | — | — | 1 | 8.00 |
| CHEMBL518752 | — | — | 1 | 7.92 |
| CHEMBL476615 | — | — | 1 | 7.66 |
| CHEMBL476822 | — | — | 1 | 7.60 |
| CHEMBL476616 | — | — | 1 | 7.58 |
| CHEMBL478682 | — | — | 1 | 7.58 |
| CHEMBL476464 | — | — | 1 | 7.48 |
| CHEMBL476821 | — | — | 1 | 7.44 |
| CHEMBL478905 | — | — | 1 | 7.32 |
| CHEMBL479105 | — | — | 1 | 7.18 |
| CHEMBL476462 | — | — | 1 | 7.08 |
| CHEMBL477066 | — | — | 1 | 6.78 |
| CHEMBL515783 | — | — | 1 | 6.74 |
| CHEMBL515780 | — | — | 1 | 6.57 |
| CHEMBL477065 | — | — | 1 | 6.47 |
| CHEMBL515789 | — | — | 1 | 6.43 |
| CHEMBL514058 | — | — | 1 | 6.41 |
| CHEMBL515939 | — | — | 1 | 6.34 |
| CHEMBL476248 | — | — | 1 | 6.33 |
| CHEMBL478073 | — | — | 1 | 6.20 |
| CHEMBL476862 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL478680 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL476463 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL177064 | — | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL518752 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL476615 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL476822 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL476616 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL478682 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL476464 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL476821 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL478905 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL479105 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL476462 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL477066 | — | Ki | = | 168.0 | nM | 6.78 |
| CHEMBL515783 | — | Ki | = | 182.0 | nM | 6.74 |
| CHEMBL515780 | — | Ki | = | 269.0 | nM | 6.57 |
| CHEMBL477065 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL515789 | — | Ki | = | 375.0 | nM | 6.43 |
| CHEMBL514058 | — | Ki | = | 392.0 | nM | 6.41 |
| CHEMBL515939 | — | Ki | = | 454.0 | nM | 6.34 |
| CHEMBL476248 | — | Ki | = | 467.0 | nM | 6.33 |
| CHEMBL478073 | — | Ki | = | 636.0 | nM | 6.20 |
| CHEMBL476862 | — | Ki | = | 646.0 | nM | 6.19 |