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Assay Detail

CHEMBL962376

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of His6x-tagged Plasmodium falciparum PfPK5 expressed in Escherichia coli by microtiter plate scintillation counting
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Plasmodium falciparum
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenones.
Geyer JA, Keenan SM, Woodard CL, Thompson PA, Gerena L, Nichols DA, Gutteridge CE, Waters NC.
Bioorg Med Chem Lett (2009) 19 : 1982 -1985
PubMed 19250824 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 4.00 4.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL446640 1 4.00
CHEMBL470424 1 -
CHEMBL16947 WR-190433 1 -
CHEMBL506696 1 -
CHEMBL221741 1 -
CHEMBL139856 1 -
CHEMBL221432 1 -
CHEMBL385631 1 -
CHEMBL218330 1 -
CHEMBL450678 1 -
CHEMBL509932 1 -
CHEMBL187682 1 -
CHEMBL471252 1 -
CHEMBL471253 1 -
CHEMBL471254 1 -
CHEMBL471667 1 -
CHEMBL187926 1 -
CHEMBL468255 1 -
CHEMBL511497 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL446640 IC50 = 100000.0 nM 4.00
CHEMBL470424 IC50 > 100000.0 nM -
CHEMBL16947 WR-190433 IC50 > 382000.0 nM -
CHEMBL506696 IC50 > 100000.0 nM -
CHEMBL221741 IC50 > 100000.0 nM -
CHEMBL139856 IC50 > 100000.0 nM -
CHEMBL221432 IC50 - -
CHEMBL385631 IC50 > 100000.0 nM -
CHEMBL218330 IC50 > 100000.0 nM -
CHEMBL450678 IC50 > 360000.0 nM -
CHEMBL509932 IC50 > 100000.0 nM -
CHEMBL187682 IC50 > 316000.0 nM -
CHEMBL471252 IC50 > 315000.0 nM -
CHEMBL471253 IC50 > 268000.0 nM -
CHEMBL471254 IC50 > 256000.0 nM -
CHEMBL471667 IC50 = 123000.0 nM -
CHEMBL187926 IC50 > 302000.0 nM -
CHEMBL468255 IC50 > 299000.0 nM -
CHEMBL511497 IC50 > 100000.0 nM -