Assay Detail
Functional
CHEMBL962639
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Cytotoxicity against human SH-SY5Y cells overexpressing dominant negative mutant of p53
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Isolation of streptonigrin and its novel derivative from Micromonospora as inducing agents of p53-dependent cell apoptosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.52 | 5.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11417 | STREPTONIGRIN | 2.0 | 1 | 5.34 |
| CHEMBL447860 | — | — | 1 | 4.12 |
| CHEMBL1233654 | — | — | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11417 | STREPTONIGRIN | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL447860 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL1233654 | — | IC50 | = | 80000.0 | nM | 4.10 |