Assay Detail
Binding
CHEMBL962685
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV1 env protein assessed as inhibition of env expressing african green monkey BSC1 cell fusion with mouse NIH3T3 cell expressing CXCR4 and Escherichia coli T7 after 2.5 hrs by beta galactosidase report gene assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | NIH3T3 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Batzelline D and isobatzelline E from the indopacific sponge Zyzzya fuliginosa.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.77 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL447517 | ISOBATZELLINE C | — | 1 | 6.70 |
| CHEMBL454072 | MAKALUVAMINE H | — | 1 | 5.30 |
| CHEMBL449905 | MAKALUVAMINE A | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL447517 | ISOBATZELLINE C | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL454072 | MAKALUVAMINE H | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL449905 | MAKALUVAMINE A | IC50 | = | 5000.0 | nM | 5.30 |