Compound Detail
CHEMBL454072
MAKALUVAMINE H Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL454072 |
| Name | MAKALUVAMINE H |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RSEQSIHJWSQOOD-UHFFFAOYSA-N |
| Parent Compound | CHEMBL465308 |
| Active Moiety | CHEMBL465308 |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
216.3
MW (Da)
0.05
ALogP
3
HBA
1
HBD
51.0
PSA (Ų)
0.62
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 5.3 | 5.3 | 5000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 5000.0 | nM | 5.3 | Inhibition of HIV1 env protein assessed as inhibition of env expressing african ... | 12027767 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12027767 | 10.1021/np010581l | Unchecked | 2 |
| 8691207 | 10.1021/np50126a008 | DNA topoisomerase 2-alpha | 1 |
| 8691207 | 10.1021/np50126a008 | HCT-116 | 1 |
Data from ChEMBL 36 via Core Engine