Assay Detail
Binding
CHEMBL963010
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Inhibition of PTP1B by pNPP assay
59
Total Activities
59
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Oleanolic acid and its derivatives: new inhibitor of protein tyrosine phosphatase 1B with cellular activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 59 | 5.76 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL499413 | — | — | 1 | 6.82 |
| CHEMBL507502 | — | — | 1 | 6.36 |
| CHEMBL504704 | — | — | 1 | 6.35 |
| CHEMBL447660 | — | — | 1 | 6.29 |
| CHEMBL446573 | — | — | 1 | 6.28 |
| CHEMBL506260 | — | — | 1 | 6.28 |
| CHEMBL508831 | — | — | 1 | 6.27 |
| CHEMBL450403 | — | — | 1 | 6.26 |
| CHEMBL452449 | — | — | 1 | 6.26 |
| CHEMBL301567 | — | — | 1 | 6.25 |
| CHEMBL449659 | — | — | 1 | 6.24 |
| CHEMBL509443 | — | — | 1 | 6.24 |
| CHEMBL509868 | — | — | 1 | 6.23 |
| CHEMBL443950 | — | — | 1 | 6.23 |
| CHEMBL510867 | — | — | 1 | 6.22 |
| CHEMBL462163 | — | — | 1 | 6.21 |
| CHEMBL506556 | — | — | 1 | 6.21 |
| CHEMBL448797 | — | — | 1 | 6.20 |
| CHEMBL443398 | — | — | 1 | 6.19 |
| CHEMBL443663 | — | — | 1 | 6.18 |
| CHEMBL501267 | — | — | 1 | 6.14 |
| CHEMBL503669 | — | — | 1 | 6.13 |
| CHEMBL445491 | — | — | 1 | 6.11 |
| CHEMBL443091 | — | — | 1 | 6.09 |
| CHEMBL504291 | — | — | 1 | 6.06 |
| CHEMBL472401 | — | — | 1 | 5.88 |
| CHEMBL472400 | — | — | 1 | 5.68 |
| CHEMBL211369 | — | — | 1 | 5.63 |
| CHEMBL472896 | — | — | 1 | 5.58 |
| CHEMBL448816 | — | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL499413 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL507502 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL504704 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL447660 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL446573 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL506260 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL508831 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL450403 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL452449 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL301567 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL449659 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL509443 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL509868 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL443950 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL510867 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL462163 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL506556 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL448797 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL443398 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL443663 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL501267 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL503669 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL445491 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL443091 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL504291 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL472401 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL472400 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL211369 | — | IC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL472896 | — | IC50 | = | 2610.0 | nM | 5.58 |
| CHEMBL448816 | — | IC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL504397 | — | IC50 | = | 2720.0 | nM | 5.57 |
| CHEMBL449967 | — | IC50 | = | 2860.0 | nM | 5.54 |
| CHEMBL506934 | — | IC50 | = | 2890.0 | nM | 5.54 |
| CHEMBL489670 | — | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL169 | URSOLIC ACID | IC50 | = | 3080.0 | nM | 5.51 |
| CHEMBL511000 | — | IC50 | = | 3190.0 | nM | 5.50 |
| CHEMBL449613 | — | IC50 | = | 3310.0 | nM | 5.48 |
| CHEMBL168 | OLEANOLIC_ACID | IC50 | = | 3370.0 | nM | 5.47 |
| CHEMBL487412 | METHYL OLEANOLATE | IC50 | = | 4440.0 | nM | 5.35 |
| CHEMBL502586 | — | IC50 | = | 4580.0 | nM | 5.34 |
| CHEMBL446005 | — | IC50 | = | 4620.0 | nM | 5.33 |
| CHEMBL461344 | — | IC50 | = | 4760.0 | nM | 5.32 |
| CHEMBL486382 | — | IC50 | = | 5050.0 | nM | 5.30 |
| CHEMBL470029 | OLEANONIC ACID | IC50 | = | 5320.0 | nM | 5.27 |
| CHEMBL391533 | COROSOLIC ACID | IC50 | = | 5490.0 | nM | 5.26 |
| CHEMBL129681 | — | IC50 | = | 5730.0 | nM | 5.24 |
| CHEMBL446073 | OLEANOLIC ACID 3-O-SUCCINATE | IC50 | = | 5970.0 | nM | 5.22 |
| CHEMBL510912 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL437964 | 11-KETO BOSWELLIC ACID | IC50 | = | 8040.0 | nM | 5.09 |
| CHEMBL445301 | — | IC50 | = | 8610.0 | nM | 5.07 |