Assay Detail
Binding
CHEMBL963011
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Inhibition of TCPTP by pNPP assay
59
Total Activities
59
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Tyrosine-protein phosphatase non-receptor type 2 (CHEMBL3807) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Oleanolic acid and its derivatives: new inhibitor of protein tyrosine phosphatase 1B with cellular activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 59 | 5.90 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL499413 | — | — | 1 | 6.80 |
| CHEMBL504704 | — | — | 1 | 6.44 |
| CHEMBL446573 | — | — | 1 | 6.35 |
| CHEMBL508831 | — | — | 1 | 6.33 |
| CHEMBL462163 | — | — | 1 | 6.32 |
| CHEMBL506556 | — | — | 1 | 6.31 |
| CHEMBL452449 | — | — | 1 | 6.30 |
| CHEMBL443950 | — | — | 1 | 6.28 |
| CHEMBL506260 | — | — | 1 | 6.28 |
| CHEMBL447660 | — | — | 1 | 6.28 |
| CHEMBL301567 | — | — | 1 | 6.26 |
| CHEMBL510867 | — | — | 1 | 6.26 |
| CHEMBL509868 | — | — | 1 | 6.23 |
| CHEMBL507502 | — | — | 1 | 6.22 |
| CHEMBL509443 | — | — | 1 | 6.20 |
| CHEMBL501267 | — | — | 1 | 6.20 |
| CHEMBL449659 | — | — | 1 | 6.19 |
| CHEMBL443398 | — | — | 1 | 6.18 |
| CHEMBL503669 | — | — | 1 | 6.17 |
| CHEMBL443091 | — | — | 1 | 6.16 |
| CHEMBL443663 | — | — | 1 | 6.12 |
| CHEMBL450403 | — | — | 1 | 6.12 |
| CHEMBL445491 | — | — | 1 | 6.10 |
| CHEMBL448797 | — | — | 1 | 6.07 |
| CHEMBL504291 | — | — | 1 | 6.07 |
| CHEMBL472401 | — | — | 1 | 5.96 |
| CHEMBL211369 | — | — | 1 | 5.86 |
| CHEMBL504397 | — | — | 1 | 5.65 |
| CHEMBL489670 | — | — | 1 | 5.60 |
| CHEMBL472400 | — | — | 1 | 5.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL499413 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL504704 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL446573 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL508831 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL462163 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL506556 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL452449 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL443950 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL506260 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL447660 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL301567 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL510867 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL509868 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL507502 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL501267 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL509443 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL449659 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL443398 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL503669 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL443091 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL443663 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL450403 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL445491 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL448797 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL504291 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL472401 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL211369 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL504397 | — | IC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL489670 | — | IC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL472400 | — | IC50 | = | 2770.0 | nM | 5.56 |
| CHEMBL448816 | — | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL472896 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL169 | URSOLIC ACID | IC50 | = | 3330.0 | nM | 5.48 |
| CHEMBL168 | OLEANOLIC_ACID | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL506934 | — | IC50 | = | 3660.0 | nM | 5.44 |
| CHEMBL446005 | — | IC50 | = | 4310.0 | nM | 5.37 |
| CHEMBL449967 | — | IC50 | = | 4550.0 | nM | 5.34 |
| CHEMBL502586 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL486382 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL129681 | — | IC50 | = | 5350.0 | nM | 5.27 |
| CHEMBL446073 | OLEANOLIC ACID 3-O-SUCCINATE | IC50 | = | 5360.0 | nM | 5.27 |
| CHEMBL470029 | OLEANONIC ACID | IC50 | = | 5630.0 | nM | 5.25 |
| CHEMBL437964 | 11-KETO BOSWELLIC ACID | IC50 | = | 9450.0 | nM | 5.03 |
| CHEMBL391533 | COROSOLIC ACID | IC50 | = | 11310.0 | nM | 4.95 |
| CHEMBL461344 | — | IC50 | - | — | - | |
| CHEMBL445301 | — | IC50 | - | — | - | |
| CHEMBL487412 | METHYL OLEANOLATE | IC50 | - | — | - | |
| CHEMBL516988 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL267225 | BOSWELLIC ACID | IC50 | > | 20000.0 | nM | - |
| CHEMBL510912 | — | IC50 | - | — | - |