Assay Detail
Binding
CHEMBL963566
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Inhibition of human recombinant MMP13 expressed in Escherichia coli
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 5.27 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL514794 | — | — | 1 | 8.10 |
| CHEMBL473107 | — | — | 1 | 6.05 |
| CHEMBL504791 | — | — | 1 | 5.77 |
| CHEMBL475540 | — | — | 1 | 5.68 |
| CHEMBL475742 | — | — | 1 | 5.60 |
| CHEMBL462629 | — | — | 1 | 5.47 |
| CHEMBL473314 | — | — | 1 | 5.46 |
| CHEMBL462628 | — | — | 1 | 5.44 |
| CHEMBL473315 | — | — | 1 | 5.40 |
| CHEMBL500351 | — | — | 1 | 5.37 |
| CHEMBL460516 | — | — | 1 | 5.33 |
| CHEMBL448246 | — | — | 1 | 5.32 |
| CHEMBL607299 | — | — | 1 | 5.17 |
| CHEMBL516952 | — | — | 1 | 5.11 |
| CHEMBL473106 | — | — | 1 | 5.09 |
| CHEMBL503470 | — | — | 1 | 5.08 |
| CHEMBL515767 | — | — | 1 | 5.03 |
| CHEMBL475541 | — | — | 1 | 5.00 |
| CHEMBL473326 | — | — | 1 | 4.99 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.99 |
| CHEMBL514495 | — | — | 1 | 4.96 |
| CHEMBL473327 | — | — | 1 | 4.92 |
| CHEMBL473313 | — | — | 1 | 4.90 |
| CHEMBL460515 | — | — | 1 | 4.88 |
| CHEMBL516029 | — | — | 1 | 4.88 |
| CHEMBL502936 | — | — | 1 | 4.82 |
| CHEMBL462627 | — | — | 1 | 4.78 |
| CHEMBL473736 | — | — | 1 | 4.63 |
| CHEMBL474933 | — | — | 1 | 4.61 |
| CHEMBL515248 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL514794 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL473107 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL504791 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL475540 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL475742 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL462629 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL473314 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL462628 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL473315 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL500351 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL460516 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL448246 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL607299 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL516952 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL473106 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL503470 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL515767 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL475541 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL473326 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL140 | CURCUMIN | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL514495 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL473327 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL473313 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL460515 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL516029 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL502936 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL462627 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL473736 | — | IC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL474933 | — | IC50 | = | 24700.0 | nM | 4.61 |
| CHEMBL515248 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL517444 | — | IC50 | > | 40000.0 | nM | - |