Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL515248

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
COc1ccc(C2C(C(C)=O)=C(C)N=c3s/c(=C\c4cc(C)n(C)c4C)c(=O)n32)c(OC)c1

Basic Information

ChEMBL ID CHEMBL515248
Phase Preclinical
Structure Type MOL
InChI Key OASXKSSRDUUVRV-NHDPSOOVSA-N
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

465.6
MW (Da)
2.80
ALogP
8
HBA
0
HBD
74.8
PSA (Ų)
0.58
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H27N3O4S
MW 465.58
Aromatic Rings 3
Heavy Atoms 33
NP-Likeness -1.38

Activity Summary

EC50 4 meas. best 5.22

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
EC50 5.22 5.135 6060.0 2
RNA-binding protein pos-1
CHEMBL1293304
EC50 4.96 4.96 10857.0 1
Zinc finger protein mex-5
CHEMBL1293319
EC50 4.68 4.68 21047.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
18358729 10.1016/j.bmc.2008.03.004 Collagenase 3 1

Data from ChEMBL 36 via Core Engine