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Assay Detail

CHEMBL963820

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against multidrug resistant Pgp expressing human LCC6 cells after 72 hrs by sulforhodamine B test
ChEMBL ↗
56
Total Activities
56
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type LCC6
Confidence 1 — Organism
Curated By Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗
Type NON-MOLECULAR

Publication

Design, synthesis, and biological evaluation of new-generation taxoids.
Ojima I, Chen J, Sun L, Borella CP, Wang T, Miller ML, Lin S, Geng X, Kuznetsova L, Qu C, Gallager D, Zhao X, Zanardi I, Xia S, Horwitz SB, Mallen-St Clair J, Guerriero JL, Bar-Sagi D, Veith JM, Pera P, Bernacki RJ.
J Med Chem (2008) 51 : 3203 -3221
PubMed 18465846 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 56 8.13 9.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL509534 — — 1 9.40
CHEMBL467163 — — 1 9.10
CHEMBL447645 — — 1 9.05
CHEMBL450955 — — 1 9.05
CHEMBL504333 — — 1 8.96
CHEMBL445708 — — 1 8.92
CHEMBL503601 — — 1 8.89
CHEMBL444419 — — 1 8.80
CHEMBL507683 — — 1 8.74
CHEMBL445812 — — 1 8.68
CHEMBL448640 — — 1 8.62
CHEMBL442936 — — 1 8.62
CHEMBL501006 — — 1 8.59
CHEMBL362146 — — 1 8.57
CHEMBL507444 — — 1 8.54
CHEMBL505678 — — 1 8.54
CHEMBL475137 — — 1 8.39
CHEMBL506232 — — 1 8.33
CHEMBL507468 — — 1 8.32
CHEMBL525615 — — 1 8.31
CHEMBL447966 — — 1 8.30
CHEMBL504170 — — 1 8.29
CHEMBL452738 — — 1 8.27
CHEMBL454022 — — 1 8.24
CHEMBL507250 — — 1 8.24
CHEMBL502402 — — 1 8.24
CHEMBL505186 — — 1 8.17
CHEMBL510418 — — 1 8.15
CHEMBL502100 — — 1 8.08
CHEMBL502400 — — 1 7.96

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL509534 — IC50 = 0.4 nM 9.40
CHEMBL467163 — IC50 = 0.8 nM 9.10
CHEMBL450955 — IC50 = 0.9 nM 9.05
CHEMBL447645 — IC50 = 0.9 nM 9.05
CHEMBL504333 — IC50 = 1.1 nM 8.96
CHEMBL445708 — IC50 = 1.2 nM 8.92
CHEMBL503601 — IC50 = 1.3 nM 8.89
CHEMBL444419 — IC50 = 1.6 nM 8.80
CHEMBL507683 — IC50 = 1.8 nM 8.74
CHEMBL445812 — IC50 = 2.1 nM 8.68
CHEMBL448640 — IC50 = 2.4 nM 8.62
CHEMBL442936 — IC50 = 2.4 nM 8.62
CHEMBL501006 — IC50 = 2.6 nM 8.59
CHEMBL362146 — IC50 = 2.7 nM 8.57
CHEMBL505678 — IC50 = 2.9 nM 8.54
CHEMBL507444 — IC50 = 2.9 nM 8.54
CHEMBL475137 — IC50 = 4.1 nM 8.39
CHEMBL506232 — IC50 = 4.7 nM 8.33
CHEMBL507468 — IC50 = 4.8 nM 8.32
CHEMBL525615 — IC50 = 4.9 nM 8.31
CHEMBL447966 — IC50 = 5.0 nM 8.30
CHEMBL504170 — IC50 = 5.1 nM 8.29
CHEMBL452738 — IC50 = 5.4 nM 8.27
CHEMBL502402 — IC50 = 5.8 nM 8.24
CHEMBL454022 — IC50 = 5.8 nM 8.24
CHEMBL507250 — IC50 = 5.7 nM 8.24
CHEMBL505186 — IC50 = 6.7 nM 8.17
CHEMBL510418 — IC50 = 7.1 nM 8.15
CHEMBL502100 — IC50 = 8.4 nM 8.08
CHEMBL502400 — IC50 = 11.0 nM 7.96
CHEMBL506225 — IC50 = 11.0 nM 7.96
CHEMBL503845 — IC50 = 12.0 nM 7.92
CHEMBL502986 — IC50 = 12.0 nM 7.92
CHEMBL510577 — IC50 = 13.0 nM 7.89
CHEMBL455233 — IC50 = 13.0 nM 7.89
CHEMBL453709 — IC50 = 13.8 nM 7.86
CHEMBL453702 — IC50 = 14.0 nM 7.85
CHEMBL502482 — IC50 = 14.0 nM 7.85
CHEMBL450892 — IC50 = 14.8 nM 7.83
CHEMBL498935 — IC50 = 15.0 nM 7.82
CHEMBL502417 — IC50 = 15.2 nM 7.82
CHEMBL503627 — IC50 = 15.2 nM 7.82
CHEMBL506777 — IC50 = 15.0 nM 7.82
CHEMBL527105 — IC50 = 16.7 nM 7.78
CHEMBL447258 — IC50 = 17.2 nM 7.76
CHEMBL454522 — IC50 = 18.0 nM 7.75
CHEMBL502942 — IC50 = 19.0 nM 7.72
CHEMBL510098 — IC50 = 20.3 nM 7.69
CHEMBL502658 — IC50 = 31.2 nM 7.51
CHEMBL501707 — IC50 = 32.0 nM 7.50