Assay Detail
Functional
CHEMBL963826
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against paclitaxel resistant human 1A9PTX10 cells expressing class 1 beta-tubulin mutant after 72 hrs
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 1A9/ptx-10 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of new-generation taxoids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.77 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL450955 | — | — | 1 | 8.44 |
| CHEMBL467163 | — | — | 1 | 8.31 |
| CHEMBL126916 | — | — | 1 | 8.05 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL450955 | — | IC50 | = | 3.65 | nM | 8.44 |
| CHEMBL467163 | — | IC50 | = | 4.91 | nM | 8.31 |
| CHEMBL126916 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 532.95 | nM | 6.27 |