Assay Detail
Binding
CHEMBL963850
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Inhibition of human recombinant PDE11
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (CHEMBL2717) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Quinazolines as potent and highly selective PDE5 inhibitors as potential therapeutics for male erectile dysfunction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.09 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL779 | TADALAFIL | 4.0 | 1 | 6.54 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 5.52 |
| CHEMBL512174 | — | — | 1 | 5.15 |
| CHEMBL471702 | — | — | 1 | 5.11 |
| CHEMBL520074 | — | — | 1 | 5.11 |
| CHEMBL488080 | — | — | 1 | 5.11 |
| CHEMBL471703 | — | — | 1 | 5.02 |
| CHEMBL521075 | — | — | 1 | 4.98 |
| CHEMBL471701 | — | — | 1 | 4.83 |
| CHEMBL471529 | — | — | 1 | 4.64 |
| CHEMBL488265 | — | — | 1 | 4.61 |
| CHEMBL513593 | — | — | 1 | 4.41 |
| CHEMBL471528 | — | — | 1 | - |
| CHEMBL470492 | — | — | 1 | - |
| CHEMBL488091 | — | — | 1 | - |
| CHEMBL487247 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL779 | TADALAFIL | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL512174 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL471702 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL520074 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL488080 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL471703 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL521075 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL471701 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL471529 | — | IC50 | = | 22700.0 | nM | 4.64 |
| CHEMBL488265 | — | IC50 | = | 24300.0 | nM | 4.61 |
| CHEMBL513593 | — | IC50 | = | 39300.0 | nM | 4.41 |
| CHEMBL471528 | — | IC50 | - | — | - | |
| CHEMBL470492 | — | IC50 | - | — | - | |
| CHEMBL488091 | — | IC50 | - | — | - | |
| CHEMBL487247 | — | IC50 | - | — | - |