Assay Detail
Binding
CHEMBL964129
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Inhibition of IGF1R by time resolved fluorescence assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Insulin-like growth factor 1 receptor (CHEMBL1957) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of multitargeted inhibitors of both the insulin-like growth factor receptor (IGF-IR) and members of the epidermal growth factor family of receptor tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.26 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL248877 | — | — | 1 | 7.60 |
| CHEMBL455208 | — | — | 1 | 7.58 |
| CHEMBL452717 | — | — | 1 | 7.57 |
| CHEMBL251732 | — | — | 1 | 7.44 |
| CHEMBL446250 | — | — | 1 | 7.40 |
| CHEMBL249496 | — | — | 1 | 7.19 |
| CHEMBL448628 | — | — | 1 | 7.16 |
| CHEMBL437584 | — | — | 1 | 7.09 |
| CHEMBL443098 | — | — | 1 | 7.09 |
| CHEMBL503638 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL248877 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL455208 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL452717 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL251732 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL446250 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL249496 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL448628 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL437584 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL443098 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL503638 | — | IC50 | = | 309.0 | nM | 6.51 |