Assay Detail
Binding
CHEMBL964133
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR phosphorylation in IGF1 and EGF-stimulated human MiaPaCa2 cells pretreated for 6 hrs before IGF1 and EGF stimulation by ELISA
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MiaPaCa2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of multitargeted inhibitors of both the insulin-like growth factor receptor (IGF-IR) and members of the epidermal growth factor family of receptor tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.51 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL443098 | — | — | 1 | 7.07 |
| CHEMBL446250 | — | — | 1 | 7.04 |
| CHEMBL455208 | — | — | 1 | 6.47 |
| CHEMBL503638 | — | — | 1 | 6.28 |
| CHEMBL452717 | — | — | 1 | 6.13 |
| CHEMBL448628 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL443098 | — | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL446250 | — | EC50 | = | 91.0 | nM | 7.04 |
| CHEMBL455208 | — | EC50 | = | 335.0 | nM | 6.47 |
| CHEMBL503638 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL452717 | — | EC50 | = | 742.0 | nM | 6.13 |
| CHEMBL448628 | — | EC50 | = | 808.0 | nM | 6.09 |