Assay Detail
Binding
CHEMBL964272
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Inhibition of human recombinant iNOS using 1 mM NADH and 2 uM L-arginine after 30 mins
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fluoropropyl)-4-methyl-pyridin-2-amine as a potential PET tracer for inducible nitric oxide synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.50 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL443862 | — | — | 1 | 7.24 |
| CHEMBL509542 | — | — | 1 | 6.77 |
| CHEMBL294609 | — | — | 1 | 6.71 |
| CHEMBL450726 | — | — | 1 | 6.66 |
| CHEMBL501620 | — | — | 1 | 6.55 |
| CHEMBL464556 | — | — | 1 | 6.16 |
| CHEMBL447472 | — | — | 1 | 6.14 |
| CHEMBL500364 | — | — | 1 | 5.75 |
| CHEMBL478130 | — | — | 1 | - |
| CHEMBL463939 | — | — | 1 | - |
| CHEMBL477457 | — | — | 1 | - |
| CHEMBL477458 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL443862 | — | IC50 | = | 57.6 | nM | 7.24 |
| CHEMBL509542 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL294609 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL450726 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL501620 | — | IC50 | = | 282.0 | nM | 6.55 |
| CHEMBL464556 | — | IC50 | = | 685.0 | nM | 6.16 |
| CHEMBL447472 | — | IC50 | = | 731.0 | nM | 6.14 |
| CHEMBL500364 | — | IC50 | = | 1776.0 | nM | 5.75 |
| CHEMBL478130 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL463939 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL477457 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL477458 | — | IC50 | > | 5000.0 | nM | - |