Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL964392

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Inhibition of CYP1A2
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Cytochrome P450 1A2 (CHEMBL3356)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Orally active C-6 heteroaryl- and heterocyclyl-substituted imidazo[1,2-a]pyridine acid pump antagonists (APAs).
Bailey N, Bamford MJ, Brissy D, Brookfield J, Demont E, Elliott R, Garton N, Farre-Gutierrez I, Hayhow T, Hutley G, Naylor A, Panchal TA, Seow HX, Spalding D, Takle AK.
Bioorg Med Chem Lett (2009) 19 : 3602 -3606
PubMed 19467868 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.00 5.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL496426 1 5.89
CHEMBL523752 1 5.82
CHEMBL238146 1 5.37
CHEMBL496606 1 4.89
CHEMBL496806 1 4.58
CHEMBL453246 1 4.46
CHEMBL496605 1 4.00
CHEMBL521889 1 -
CHEMBL447822 1 -
CHEMBL496400 1 -
CHEMBL497011 LINAPRAZAN 2.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL496426 IC50 = 1300.0 nM 5.89
CHEMBL523752 IC50 = 1500.0 nM 5.82
CHEMBL238146 IC50 = 4300.0 nM 5.37
CHEMBL496606 IC50 = 13000.0 nM 4.89
CHEMBL496806 IC50 = 26000.0 nM 4.58
CHEMBL453246 IC50 = 35000.0 nM 4.46
CHEMBL496605 IC50 = 100000.0 nM 4.00
CHEMBL521889 IC50 > 100000.0 nM -
CHEMBL447822 IC50 > 100000.0 nM -
CHEMBL496400 IC50 > 100000.0 nM -
CHEMBL497011 LINAPRAZAN IC50 > 100000.0 nM -