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Assay Detail

CHEMBL964475

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Binding
Inhibition of pig D-amino acid oxidase
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Sus scrofa
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

D-amino-acid oxidase (CHEMBL6172)
Type SINGLE PROTEIN
Organism Sus scrofa

Publication

Synthesis and biological evaluation of D-amino acid oxidase inhibitors.
Ferraris D, Duvall B, Ko YS, Thomas AG, Rojas C, Majer P, Hashimoto K, Tsukamoto T.
J Med Chem (2008) 51 : 3357 -3359
PubMed 18507366 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 5.81 6.73

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL445990 1 6.73
CHEMBL455499 1 6.57
CHEMBL482936 1 6.35
CHEMBL455217 1 6.22
CHEMBL509741 1 6.14
CHEMBL482935 1 5.82
CHEMBL444173 1 5.73
CHEMBL483504 1 5.59
CHEMBL472830 1 5.53
CHEMBL455701 1 5.30
CHEMBL506718 1 5.11
CHEMBL502301 1 4.64
CHEMBL483331 1 -
CHEMBL273481 MUSCIMOL 1.0 1 -
CHEMBL509291 1 -
CHEMBL2372284 1 -
CHEMBL450983 1 -
CHEMBL483503 1 -
CHEMBL519657 1 -
CHEMBL506276 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL445990 IC50 = 188.0 nM 6.73
CHEMBL455499 IC50 = 269.0 nM 6.57
CHEMBL482936 IC50 = 444.0 nM 6.35
CHEMBL455217 IC50 = 599.0 nM 6.22
CHEMBL509741 IC50 = 722.0 nM 6.14
CHEMBL482935 IC50 = 1510.0 nM 5.82
CHEMBL444173 IC50 = 1880.0 nM 5.73
CHEMBL483504 IC50 = 2570.0 nM 5.59
CHEMBL472830 IC50 = 2950.0 nM 5.53
CHEMBL455701 IC50 = 5000.0 nM 5.30
CHEMBL506718 IC50 = 7820.0 nM 5.11
CHEMBL502301 IC50 = 23000.0 nM 4.64
CHEMBL483331 IC50 > 100000.0 nM -
CHEMBL273481 MUSCIMOL IC50 > 100000.0 nM -
CHEMBL509291 IC50 > 100000.0 nM -
CHEMBL2372284 IC50 > 100000.0 nM -
CHEMBL450983 IC50 > 100000.0 nM -
CHEMBL483503 IC50 > 100000.0 nM -
CHEMBL519657 IC50 > 100000.0 nM -
CHEMBL506276 IC50 > 100000.0 nM -