Assay Detail
Functional
CHEMBL964516
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Oocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Gamma-aminobutyric acid type B receptor subunit 1 (CHEMBL2064) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel gamma-aminobutyric acid rho1 receptor antagonists; synthesis, pharmacological activity and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 4.62 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | 1.0 | 1 | 5.77 |
| CHEMBL504482 | — | — | 1 | 4.29 |
| CHEMBL447171 | — | — | 1 | 4.28 |
| CHEMBL445449 | — | — | 1 | 4.14 |
| CHEMBL397209 | — | — | 1 | - |
| CHEMBL355921 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL504482 | — | EC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL447171 | — | EC50 | = | 52200.0 | nM | 4.28 |
| CHEMBL445449 | — | EC50 | = | 71900.0 | nM | 4.14 |
| CHEMBL397209 | — | EC50 | = | 500000.0 | nM | - |
| CHEMBL355921 | — | EC50 | - | — | - |