Assay Detail
Functional
CHEMBL964705
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mu opioid receptor in guinea pig ileum assessed as inhibition of electrically-stimulated contraction
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity study of endomorphin-2 analogs with C-terminal modifications by NMR spectroscopy and molecular modeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.89 | 8.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333357 | ENDOMORPHIN 2 | — | 1 | 8.02 |
| CHEMBL522293 | — | — | 1 | 7.53 |
| CHEMBL361922 | — | — | 1 | 7.38 |
| CHEMBL505502 | — | — | 1 | 7.19 |
| CHEMBL180777 | — | — | 1 | 6.88 |
| CHEMBL453689 | — | — | 1 | 6.87 |
| CHEMBL505975 | — | — | 1 | 5.74 |
| CHEMBL500195 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333357 | ENDOMORPHIN 2 | IC50 | = | 9.67 | nM | 8.02 |
| CHEMBL522293 | — | IC50 | = | 29.3 | nM | 7.53 |
| CHEMBL361922 | — | IC50 | = | 42.1 | nM | 7.38 |
| CHEMBL505502 | — | IC50 | = | 64.41 | nM | 7.19 |
| CHEMBL180777 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL453689 | — | IC50 | = | 136.2 | nM | 6.87 |
| CHEMBL505975 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL500195 | — | IC50 | = | 3002.0 | nM | 5.52 |