Assay Detail
Functional
CHEMBL964938
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Antiproliferative activity against human HN5 cells overexpressing EGFR after 3 days
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HN5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of aniline headgroups for alkynyl thienopyrimidine dual EGFR/ErbB-2 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.47 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL510845 | — | — | 1 | 7.16 |
| CHEMBL507821 | — | — | 1 | 7.16 |
| CHEMBL503253 | — | — | 1 | 7.16 |
| CHEMBL452716 | — | — | 1 | 6.92 |
| CHEMBL500217 | — | — | 1 | 6.72 |
| CHEMBL504117 | — | — | 1 | 6.62 |
| CHEMBL500072 | — | — | 1 | 6.60 |
| CHEMBL507329 | GW869810X | — | 1 | 6.58 |
| CHEMBL455434 | — | — | 1 | 6.57 |
| CHEMBL453398 | — | — | 1 | 6.55 |
| CHEMBL501050 | — | — | 1 | 6.51 |
| CHEMBL452980 | — | — | 1 | 6.50 |
| CHEMBL457250 | — | — | 1 | 6.42 |
| CHEMBL505463 | — | — | 1 | 6.41 |
| CHEMBL508760 | — | — | 1 | 6.36 |
| CHEMBL449949 | — | — | 1 | 6.31 |
| CHEMBL451074 | — | — | 1 | 6.27 |
| CHEMBL451347 | — | — | 1 | 6.26 |
| CHEMBL452768 | — | — | 1 | 6.20 |
| CHEMBL461811 | — | — | 1 | 5.84 |
| CHEMBL447720 | — | — | 1 | 5.70 |
| CHEMBL455433 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL510845 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL507821 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL503253 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL452716 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL500217 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL504117 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL500072 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL507329 | GW869810X | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL455434 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL453398 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL501050 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL452980 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL457250 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL505463 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL508760 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL449949 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL451074 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL451347 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL452768 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL461811 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL447720 | — | IC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL455433 | — | IC50 | = | 3470.0 | nM | 5.46 |