Assay Detail
Binding
CHEMBL964949
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Inhibition of VEGFR3 by virtual HTS assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Vascular endothelial growth factor receptor 3 (CHEMBL1955) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
N-substituted 2'-(aminoaryl)benzothiazoles as kinase inhibitors: hit identification and scaffold hopping.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.47 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL460746 | — | — | 1 | 6.00 |
| CHEMBL522785 | — | — | 1 | 5.80 |
| CHEMBL518803 | — | — | 1 | 5.68 |
| CHEMBL301018 | — | — | 1 | 5.62 |
| CHEMBL491686 | — | — | 1 | 5.60 |
| CHEMBL475352 | — | — | 1 | 5.47 |
| CHEMBL459886 | — | — | 1 | 5.28 |
| CHEMBL464014 | — | — | 1 | 5.22 |
| CHEMBL461991 | — | — | 1 | 5.19 |
| CHEMBL512933 | — | — | 1 | 5.16 |
| CHEMBL475351 | — | — | 1 | 5.11 |
| CHEMBL474347 | — | — | 1 | - |
| CHEMBL474346 | — | — | 1 | - |
| CHEMBL514929 | — | — | 1 | - |
| CHEMBL472946 | — | — | 1 | - |
| CHEMBL462338 | — | — | 1 | - |
| CHEMBL462162 | — | — | 1 | - |
| CHEMBL461110 | — | — | 1 | - |
| CHEMBL462160 | — | — | 1 | - |
| CHEMBL464210 | — | — | 1 | - |
| CHEMBL462161 | — | — | 1 | - |
| CHEMBL461109 | — | — | 1 | - |
| CHEMBL515598 | — | — | 1 | - |
| CHEMBL490555 | — | — | 1 | - |
| CHEMBL443906 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL460746 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL522785 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL518803 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL301018 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL491686 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL475352 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL459886 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL464014 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL461991 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL512933 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL475351 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL474347 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL474346 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL514929 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL472946 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL462338 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL462162 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL461110 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL462160 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL464210 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL462161 | — | IC50 | - | — | - | |
| CHEMBL461109 | — | IC50 | - | — | - | |
| CHEMBL515598 | — | IC50 | - | — | - | |
| CHEMBL490555 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL443906 | — | IC50 | - | — | - |